Table 2.
Cluster analysis yielded the above instruments under corresponding domains with median/mean scores reported. [--] signifies this was no longer considered relevant to that disease.
| DOMAIN | INSTRUMENTS | CTD ILD Median / mean |
IPF Median /mean |
|---|---|---|---|
| Dyspnea | Borg Dyspnea Index | 7.0 / 6.9 | 7.0/7.0 |
| Dyspnea 12 | [7.0 / 6.6] | 7.0 / 6.7 | |
| Medical Research Council (MRC) Breathlessness (Chronic Dyspnea) Scale or the Modified MRC Dyspnea Scale | 7.0 / 7.0 | 7.0 / 7.1 | |
| Borg Dyspnea Index - Pre and Post Exercise | 7.0 / 7.0 | [7.0 / 7.1] | |
| Health Related Quality of Life (HRQoL) | Medical Outcomes Survey Short Form -36 Questionnaire (SF-36) | 7.0 / 7.3 | 7.0 / 7.3 |
| St. George’s Dyspnea Respiratory Questionnaire | [7.0 /6.6] | 7.0 / 6.8 | |
| Visual Analogue Scale of Patient Assessment of Disease Activity | 7.0 / 6.8 | 7.0 / 6.7 | |
| Ability to Carry Out Activities of Daily Living (ADLs) | 7.0 / 6.8 | Lost Tier1 | |
| Health Assessment Questionnaire Disability Index (HAQ-DI) | 7.0 / 7.0 | Lost Tier 1 | |
| Lung Imaging | Extent of Honeycombing on HRCT | 7.0 / 7.1 | 8.0 / 7.4 |
| Extent of Reticulation on HRCT | [7.0 / 6.9] | 7.0 / 6.9 | |
| Extent of Ground Glass Opacities on HRCT | 7.0 / 7.2 | [7.0 / 6.7] | |
| Overall Extent of Interstitial Lung Disease on HRCT | 8.0 / 7.7 | 8.0 / 7.7 | |
| Lung Physiology / Function | Supplemental Oxygen Requirement | 7.0 / 7.3 | 8.0 / 7.5 |
| Forced Vital Capacity on Spirometry | 8.0 / 8.3 | 9.0 / 8.3 | |
| Diffusion Capacity of Lung for Carbon Dioxide | 8.0 / 7.9 | 8.0 / 7.9 | |
| 6 MWT with Maximal Desaturation on Pulse Oximetry | 7.0 / 6.8 | 7.0 / 7.0 | |
| 6 MWT for Distance | [7.0 / 6.5] | 7.0 / 7.0 | |
| Survival | Time to Decline in Forced Vital Capacity | 7.0 / 7.3 | 7.0 / 7.0 |
| Progression Free Survival | 8.0 / 8.2 | 8.0 / 8.3 | |
| Time to Death | 7.0 / 7.1 | 8.0 / 7.3 |