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Schematic diagram of the mechanism whereby miR-16 attenuation contributes to myocardial hypertrophy. Activation of the STAT3/c-Myc signalling pathway negatively regulates miR-16 expression during cardiac hypertrophy. In addition, attenuation of miR-16 derepresses the cyclins D1, D2 and E1 and activates cyclin/Rb pathway to provoke cardiomyocyte hypertrophy.
