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. 2015 Feb 25;19(3):651–663. doi: 10.1111/jcmm.12469

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig 2 — Effects of 17-AAG on the expression of LATS1, p-LATS1, YAP and CTGF. (A and B) The mRNA expression levels of YAP and CTGF, indicated by Real-time PCR assay, were markedly decreased, while those of LATS1 and p-LATS1 were increased in 17-AAG treated groups for 24 hrs compared to the untreated group (each **P < 0.01). (C) The expression levels of YAP and CTGF proteins, indicated by Western blot assay, were down-regulated, while LATS1 was upregulated in a dose-dependent manner in 17-AAG treated groups compared to the untreated group.