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. 2013 Apr;2(2):72–86. doi: 10.3978/j.issn.2218-6751.2013.03.1

Figure 2.

Figure 2

Molecular structure of crizotinib co-crystalized with (A) ALKwt receptor, PDB ID: 2XP2; and (B) ALKL1196M mutant, PDB ID: 2YFX. Although Lys-Met exchange the binding mode of crizotinib remains unchanged. Structures analysis has been performed and rendered using MOE software (48).