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. 2015 Mar 23;6:129. doi: 10.3389/fimmu.2015.00129

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Copyright © 2015 Durand and Segura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional specialization of human DC subsets. Schematic representation of known and unknown functional specialization of migratory and resident DC subsets, and inflammatory DCs. Cytokines specifically expressed by a given DC subset are indicated. The ability to present antigens to CD8 or CD4 T cells is represented with red or blue arrows, respectively. The ability of DC subsets to induce cytotoxic T lymphocyte (CTL) differentiation, regulatory T (Treg), or helper T (Th) cell polarization is indicated. Question marks indicate unknown functions and crosses indicate functions that are not performed by a given DC subset.