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. 2015 Mar 9;2015:328707. doi: 10.1155/2015/328707

Figure 1.

Figure 1

Effect of WTD on mechanical hypersensitivity induced by CFA in mice. (a) Effect of WTD on mechanical hypersensitivity. Mice were orally administrated with WTD (1.58, 3.15, and 6.30 g/kg, resp.), ibuprofen (0.14 g/kg), or water daily for 15 days. (b) WTD has no tolerance effect. CFA-induced inflammatory pain mice were administrated with WTD (6.30 g/kg, p.o.) daily for 11 days. Treatment of WTD was interrupted for 2 days and then reestablished on 14th day. On 1st and 14th days, evaluations for mechanical hypersensitivity were done 0, 1, 2, 3, 4, and 24 hours posttreatment; all other evaluations were done 1 hour posttreatment. (c) Effect of WTD (1.58, 3.15, and 6.30 g/kg, resp., p.o.) and ibuprofen (0.14 g/kg, p.o.) on body weights change 15 days posttreatment. Data are represented as the mean ± SEM (n = 11). # P < 0.05 versus the control group; * P < 0.05, ** P < 0.01, and *** P < 0.001 versus the CFA group, respectively.