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Effect of WTD on cold hypersensitivity induced by CFA in mice. Mice were orally administrated with WTD (1.58, 3.15, and 6.30 g/kg, resp.), ibuprofen (0.14 g/kg), or water daily for 15 days. On 1st day, evaluations for cold hypersensitivity were done 0.5, 1, 2, 4, 6, 8, and 10 hours posttreatment; all other evaluations were done 1 hour posttreatment. Data are represented as the mean ± SEM (n = 11). * P < 0.05 and *** P < 0.001 versus the CFA group, respectively.
