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Effect of WTD on heat hypersensitivity induced by CFA in mice. Mice were orally administrated with WTD (1.58, 3.15, and 6.30 g/kg, resp.), ibuprofen (0.14 g/kg), or water daily for 15 days. On 1st day, evaluations for heat hypersensitivity were done 0.5, 1, 1.5, 2, 3, 4, and 6 hours posttreatment; all other evaluations were done 1 hour posttreatment. Data are represented as the mean ± SEM (n = 8). * P < 0.05, ** P < 0.01, and *** P < 0.001 versus the CFA group, respectively.
