Table 2.

Distribution of CYP26 families genotype and allele frequency among malignant oral disorders patients and control groups.

	Oral and pharyngeal cancer (N = 211)	OPMDs (N = 56)	Controls (N = 218)	Oral and pharyngeal cancer versus controls		OPMDs versus controls
BQ chewers	N (%)	N (%)	N (%)	aOR (95% CI)	P	aOR (95% CI)	P
CYP26A1
rs4411227
Genotype
G/G	130 (61.61)	40 (71.43)	170 (77.98)	1.00		1.00
C/G	74 (35.07)	14 (25.00)	43 (19.72)	2.38 (1.48–3.84)b∗	0.0004	1.39 (0.67–2.90)	0.3792
C/C	7 (3.32)	2 (3.57)	5 (2.29)	1.65 (0.46–5.95)	0.4417	0.80 (0.09–7.46)	0.8430
Combined genotype
G/G	130 (61.61)	40 (71.43)	170 (77.98)	1.00		1.00
C/C + C/G	81 (38.39)	16 (28.57)	48 (22.02)	2.30 (1.45–3.64)*	0.0004	1.33 (0.65–2.70)	0.4389
Allele
G	334 (79.15)	94 (83.93)	383 (87.84)	1.00		1.00
C	88 (20.85)	18 (16.07)	53 (12.16)	1.93 (1.30–2.88)*	0.0012	1.22 (0.65–2.29)	0.5447
CYP26B1
rs887844
Genotype
G/G	115 (54.50)	25 (44.64)	133 (61.01)	1.00		1.00
A/G	96 (45.50)	31 (55.36)	85 (38.99)	1.38 (0.91–2.09)	0.1273	1.87 (1.01–3.49)*	0.0482
Allele
G	326 (77.25)	81 (72.32)	351 (80.50)	1.00		1.00
A	96 (22.75)	31 (27.68)	85 (19.50)	1.26 (0.89–1.80)	0.1941	1.55 (0.93–2.57)	0.0898
rs3768647
C/G	103 (48.82)	34 (60.71)	218 (100.00)	1.00		1.00
G/G	108 (51.18)	22 (39.29)	0 (0.00)	—a		—a
Allele
C	103 (24.41)	34 (30.36)	218 (50.00)	1.00		1.00
G	319 (75.59)	78 (69.64)	218 (50.00)	3.12 (2.28–4.27)*	<0.0001	2.23 (1.40–3.54)*	0.0007
rs9309462
T/T	198 (93.84)	52 (92.86)	216 (99.08)	1.00		1.00
C/T	13 (6.16)	4 (7.14)	2 (0.92)	9.24 (1.90–45.00)*	0.0059	8.17 (1.25–53.52)*	0.0285
Allele
T	409 (96.92)	108 (96.43)	434 (99.54)	1.00		1.00
C	13 (3.08)	4 (3.57)	2 (0.46)	8.86 (1.84–42.59)*	0.0065	7.87 (1.22–50.54)*	0.0298

aOR was adjusted by continuous age, ethnicity, education level, alcohol drinking, and cigarette smoking habits.

^aNonestimated: because the number of samples is equal to zero.

^b∗ P < 0.05.