Table 2.

Differentially expressed genes related to calcium pathway in old versus old nitrate treated mice.

Gene symbol	Description	Regulation	Fold change	P value
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	Up	1.2	0.010
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	Up	1.3	0.018
Ptk2b	PTK2 protein tyrosine kinase 2 beta	Down	1.2	0.008
Adcy7	Adenylate cyclase 7	Up	1.4	0.001
Adra1a	Adrenergic receptor, alpha 1a	Down	1.5	0.002
Adrb3	Adrenergic receptor, beta 3	Down	1.9	0.004
Cacna1d	Calcium channel, voltage-dependent, L type, alpha 1D subunit	Up	1.4	0.013
Ppapdc2	Calcium channel, voltage-dependent, L type, alpha 1S subunit	Down	1.3	0.010
Camk4	Calcium/calmodulin-dependent protein kinase IV	Up	1.4	0.009
F2r	Coagulation factor II (thrombin) receptor	Up	1.3	0.001
Ednrb	Endothelin receptor type B	Down	1.2	0.045
Gna14	Guanine nucleotide binding protein, alpha 14	Up	1.6	0.031
Itpr2	Inositol 1,4,5-triphosphate receptor 2	Down	1.3	0.001
Itpr3	Inositol 1,4,5-triphosphate receptor 3	Up	1.2	0.024
Itpka	Inositol 1,4,5-trisphosphate 3-kinase A	Down	1.4	0.017
Nos2	Nitric oxide synthase 2, inducible	Down	1.2	0.019
Oxtr	Oxytocin receptor	Down	1.4	0.042
Plcb4	Phospholipase C, beta 4	Up	1.4	0.005
Plcd1	Phospholipase C, delta 1	Up	1.2	0.001
Phka2	Phosphorylase kinase alpha 2	Down	1.2	0.037
Pdgfrb	Platelet derived growth factor receptor, beta polypeptide	Up	1.2	0.007
Calm2	Calmodulin 2	Up	1.2	0.020
Ptger1	Prostaglandin E receptor 1 (subtype EP1)	Up	1.2	0.023
Ptger3	Prostaglandin E receptor 3 (subtype EP3)	Down	1.9	0.020
Prkx	Protein kinase, X-linked	Down	1.2	0.031
Ppp3cc	Protein phosphatase 3, catalytic subunit, gamma isoform	Down	1.3	0.025
P2rx3	Purinergic receptor P2X, ligand-gated ion channel, 3	Up	1.3	0.035
Ryr2	Ryanodine receptor 2, cardiac	Up	1.4	0.007
Camk2g	Similar to Calcium/calmodulin-dependent protein kinase type II gamma chain	Up	1.3	0.010
Sphk2	Sphingosine kinase 2	Down	1.2	0.021