Table 3.

Enriched genes associated with the biological process of detoxification, antioxidation, and free radical removal, according to Panther Gene Ontology in old versus old nitrate treated mice.

Gene symbol	Description	Regulation	Fold change	P value
pAbcc1	ATP-binding cassette, subfamily C (CFTR/MRP), member 1	Up	1.2	0.007
Asna1	arsA arsenite transporter, ATP-binding	Down	1.2	0.025
Ces1d	Carboxyl esterase 3	Down	1.4	0.002
Ces1f	Expressed sequence AU018778	Down	1.6	0.010
Ephx1	Epoxide hydrolase 1, microsomal	Up	1.3	0.015
Gpx3	Glutathione peroxidase 3	Down	1.5	0.001
Gpx4	Heterogeneous nuclear ribonucleoprotein L-like; glutathione peroxidase 4	Down	1.4	0.003
Gsta3	Glutathione S-transferase, alpha 3	Down	2.1	0.039
Gsta4	Glutathione S-transferase, alpha 4	Down	1.5	0.010
Gstm4	Glutathione S-transferase, mu 4	Down	1.3	0.009
Gstt3	Glutathione S-transferase, theta 3	Up	1.2	0.020
Gstz1	Glutathione transferase zeta 1	Down	1.3	0.034
Haghl	Hydroxyacyl glutathione hydrolase-like	Up	1.2	0.006
Mgst1	Microsomal glutathione S-transferase 1	Down	1.3	0.044
Mgst2	Microsomal glutathione S-transferase 2	Down	1.7	0.015
Mgst3	Microsomal glutathione S-transferase 3	Down	1.2	0.044
Mpv17l	Mpv17 transgene, kidney disease mutant-like	Up	1.3	0.001
Nos2	Nitric oxide synthase 2, inducible	Down	1.2	0.019
Pnkd	Paroxysmal nonkinesiogenic dyskinesia	Down	1.4	0.030
Pon3	Paraoxonase 3	Down	1.2	0.002
Prdx4	Peroxiredoxin 4	Up	1.2	0.001
Prdx5	Peroxiredoxin 5	Down	1.2	0.011
Pxmp2	Peroxisomal membrane protein 2	Down	1.2	0.011
Sod1	Superoxide dismutase 1, soluble	Down	1.2	0.015
Sod3	Superoxide dismutase 3, extracellular	Up	1.2	0.015
Tst	Thiosulfate sulfotransferase, mitochondrial	Down	1.3	0.037
Txndc16	Thioredoxin domain containing 16	Up	1.2	0.009
Txnl4a	Thioredoxin-like 4A	Down	1.2	0.002