Table 6.
Estimated haplotype frequency of the rs599839, rs646776, and rs4970834 polymorphisms in chromosomal locus 1p13.3 and its associations with the severity of coronary artery lesion in coronary artery disease (CAD) patients for significant stenosis versus nonsignificant stenosis outcome.
| rs599839 | rs4970834 | rs646776 | Haplotype |
EM frequency ≥50% |
EM frequency <50% |
Adjusted OR, 95% Cl |
P value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| A | G | C | T | T | C | |||||
| A | G | C | T | T | C | ATC | 0.284 | 0.364 | 0.69 (0.46–1.05) |
0.090 |
| A | G | C | T | T | C | GTC | 0.295 | 0.178 | 0.54 (0.21–0.96) |
0.005 |
| A | G | C | T | T | C | ACC | 0.186 | 0.219 | 0.82 (0.51–1.32) |
0.410 |
| A | G | C | T | T | C | GCC | 0.093 | 0.135 | 0.66 (0.36–1.21) |
0.172 |
| A | G | C | T | T | C | GCT | 0.061 | 0.034 | 1.85 (0.70–4.89) |
0.208 |
| A | G | C | T | T | C | ATT | 0.043 | 0.058 | 0.73 (0.30–1.74) |
0.471 |
| A | G | C | T | T | C | GTT | 0.028 | 0.007 | 4.00 (0.58–27.57) |
0.128 |
Data are presented as frequency for severity of coronary artery lesion in CAD patients with significant lesion (≥50%) versus insignificant stenosis (<50%) for each haplotype with the odds ratio, lower and upper 95% confidence intervals, and P value. The data were analyzed by logistic regression analysis. ORs were adjusted for age, gender, BMI, type 2 diabetes, smoking, hypertension, and lipid-lowering therapy. Two-tailed P value is significant <0.05.