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. 2015 Mar 23;2:18. doi: 10.3389/fmed.2015.00018

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Copyright © 2015 Carlier and Bailly.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Left: 3D visualization of two tumors (T2 and T3) using parametric imaging with three basis functions: stable (blue), decreasing (green), and increasing (red) represented in the left corner of each image (the number of chemotherapy courses between each PET exam is mentioned). Parametric imaging using 2 (A), 3 (B), 4 (C), and 5 (D) exams. Right: SUV_mean evolution (calculated within a ROI defined by 40% of SUV_max) for the two tumors. Note that the non-responding T2 tumor was detected with parametric imaging earlier (exam 2) than applying EORTC criteria that concluded to a stable disease between exam 2 and 3. Reprinted by permission of Necib (Ph.D Thesis).