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. Author manuscript; available in PMC: 2015 Mar 23.
Published in final edited form as: Methods Mol Biol. 2014;1144:265–281. doi: 10.1007/978-1-4939-0428-0_18

Figure 4.

Figure 4

Zernike phase contrast imaging. HSV capsids imaged under conventional cryo-EM conditions are characteristically low contrast (A). The same sample when imaged with Zernike phase contrast cryo-EM has markedly increased contrast (B).