Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Exp Neurol. 2014 Sep 20;263:221–234. doi: 10.1016/j.expneurol.2014.09.010

Table 1.

Differentially regulated genes in brains of METH-treated gp120tg and WT mice and vehicle-treated gp120tg mice.

Group Gene Description Reference
sequence
Reference Neuro-
trans-
mitter
system
Pre- or
postsyna
ptic
location
Fold
change
p value
WT
METH

vs.

WT
SAL
(ctl)
Bdnf Brain derived neurotrophic
factor
NM_007540 Barde et al., 1982 GABA,
glutamate
NA 0.818 0.034
Cdk5r1 Cyclin-dependent kinase 5,
regulatory subunit 1 (p35)
NM_009871 Tsai et al., 1994 glutamate NA 1.168 0.018
Itpr1 Inositol 1,4,5-trisphosphate
receptor 1
NM_010585 Maeda et al., 1988 glutamate NA 0.727 0.0002
Slc17a7/
Vglut1
Solute carrier family 17
(sodium-dependent inorganic
phosphate cotransporter),
member 7; vesicular glutamate
transporter 1
NM_182993 Takamori et al., 2000
Bellocchio et al., 2000
glutamate pre 1.176 0.037
gp120
SAL

vs.

WT
SAL
(ctl)
Gabrg1 Gamma-aminobutyric acid
(GABA) A receptor, subunit
gamma 1
NM_010252 Wilcox et al., 1992 GABA post 0.837 0.002
Gabrg2 Gamma-aminobutyric acid
(GABA) A receptor, subunit
gamma 2
NM_008073 Wilcox et al., 1992 GABA post 0.796 0.028
Gria4 Glutamate receptor, ionotropic,
AMPA4 (alpha 4)
NM_019691 Sommer et al., 1991 glutamate post 0.877 0.014
Grin2c Glutamate receptor, ionotropic,
NMDA2C (epsilon 3)
NM_010350 Ebralidze et al., 1996 glutamate post 0.746 0.015
Slc1a6/
Eaat4
Solute carrier family 1 (high
affinity aspartate/glutamate
transporter), member 6;
excitatory amino-acid
transporter 4
NM_009200 Yamada et al., 1997 glutamate post 0.883 0.028
gp120
METH

vs.

WT
SAL
(ctl)
Abat 4-aminobutyrate
aminotransferase, GABA-
transaminase
NM_172961 Abel et al., 1999 GABA pre 0.846 0.036
Adora1 Adenosine A1 receptor NM_001008533 Johansson et al., 2001 GABA,
glutamate
pre and
post
0.730 0.037
Cacna1b Calcium channel, voltage-
dependent, N type, alpha 1B
subunit
NM_007579 Coppola et al., 1994 GABA pre 0.743 0.005
Gabra2 Gamma-aminobutyric acid
(GABA) A receptor, subunit
alpha 2
NM_008066 Buckle et al., 1989 GABA post 0.878 0.037
Gabrg1 Gamma-aminobutyric acid
(GABA) A receptor, subunit
gamma 1
NM_010252 Wilcox et al., 1992 GABA post 0.768 0.010
Gnai1 Guanine nucleotide binding
protein (G protein), alpha
inhibiting 1
NM_010305 Sullivan et al., 1986 GABA,
glutamate
NA 0.788 0.033
Itpr1 Inositol 1,4,5-trisphosphate
receptor 1
NM_010585 Maeda et al., 1988 GABA NA 0.684 0.016
gp120
METH

vs.

WT
METH
(ctl)
Adora1 Adenosine A1 receptor NM_001008533 Johansson et al., 2001 GABA,
glutamate
pre and
post
0.730 0.027
Cdk5r1 Cyclin-dependent kinase 5,
regulatory subunit 1 (p35)
NM_009871 Tsai et al., 1994 glutamate NA 0.726 0.020
Gria1 Glutamate receptor, ionotropic,
AMPA1 (alpha 1)
NM_008165 Puckett et al., 1991 glutamate post 0.868 0.025
Grik5 Glutamate receptor, ionotropic,
kainate 5 (gamma 2)
NM_010350 Szpirer et al., 1994 glutamate post 0.429 0.00007
Nsf N-ethylmaleimide sensitive
fusion protein
NM_008740 Block et al., 1988 GABA,
glutamate
pre 0.854 0.026
Slc17a7/
Vglut1
Solute carrier family 17
(sodium-dependent inorganic
phosphate cotransporter),
member 7; vesicular glutamate
transporter 1
NM_182993 Takamori et al., 2000
Bellocchio et al., 2000
glutamate pre 0.697 0.014
gp120
SAL

vs.

WT
METH
(ctl)
Cdk5r1 Cyclin-dependent kinase 5,
regulatory subunit 1 (p35)
NM_009871 Tsai et al., 1994 glutamate NA 1.146 0.031
Slc1a3/
Eaat1/
Glast
Solute carrier family 1 (high
affinity aspartate/glutamate
transporter), member 6,
EAAT1, GLAST
NM_009200 Takai et al., 1995 glutamate NA 0.837 0.049
Slc7a11 Solute carrier family 7 (cationic
amino acid transporter, y+
system), member 11
NM_011990 Sato et al., 1999 glutamate NA 0.438 0.035
gp120
METH

vs.

gp120
SAL
(ctl)
Gnai1 Guanine nucleotide binding
protein (G protein), alpha
inhibiting 1
NM_010305 Sullivan et al., 1986 GABA and
glutamate
NA 0.836 0.034
Gria3 Glutamate receptor, ionotropic,
AMPA3 (alpha 3)
NM_016886 Sato et al., 1993 glutamate post 0.880 0.017

Differentially regulated genes in brains of METH-treated gp120tg and WT mice and vehicle-treated gp120tg mice. List of 20 genes that were found to be significantly differentially regulated using a GABA and glutamate RT2 Profiler PCR Array. The following information is provided: experimental group (ctl = control condition in the given comparison) abbreviated and full gene name, sequence number in GenBank, references, indication to which neurotransmitter system the gene belongs, synaptic localization (if applicable), fold change (ctl condition = 1) and p-values for the respective comparisons.