Table 1.

Differentially regulated genes in brains of METH-treated gp120tg and WT mice and vehicle-treated gp120tg mice.

Group	Gene	Description	Reference sequence	Reference	Neuro- trans- mitter system	Pre- or postsyna ptic location	Fold change	p value
WT METH vs. WT SAL (ctl)	Bdnf	Brain derived neurotrophic factor	NM_007540	Barde et al., 1982	GABA, glutamate	NA	0.818	0.034
	Cdk5r1	Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	NM_009871	Tsai et al., 1994	glutamate	NA	1.168	0.018
	Itpr1	Inositol 1,4,5-trisphosphate receptor 1	NM_010585	Maeda et al., 1988	glutamate	NA	0.727	0.0002
	Slc17a7/ Vglut1	Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; vesicular glutamate transporter 1	NM_182993	Takamori et al., 2000 Bellocchio et al., 2000	glutamate	pre	1.176	0.037
gp120 SAL vs. WT SAL (ctl)	Gabrg1	Gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	NM_010252	Wilcox et al., 1992	GABA	post	0.837	0.002
	Gabrg2	Gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	NM_008073	Wilcox et al., 1992	GABA	post	0.796	0.028
	Gria4	Glutamate receptor, ionotropic, AMPA4 (alpha 4)	NM_019691	Sommer et al., 1991	glutamate	post	0.877	0.014
	Grin2c	Glutamate receptor, ionotropic, NMDA2C (epsilon 3)	NM_010350	Ebralidze et al., 1996	glutamate	post	0.746	0.015
	Slc1a6/ Eaat4	Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; excitatory amino-acid transporter 4	NM_009200	Yamada et al., 1997	glutamate	post	0.883	0.028
gp120 METH vs. WT SAL (ctl)	Abat	4-aminobutyrate aminotransferase, GABA- transaminase	NM_172961	Abel et al., 1999	GABA	pre	0.846	0.036
	Adora1	Adenosine A1 receptor	NM_001008533	Johansson et al., 2001	GABA, glutamate	pre and post	0.730	0.037
	Cacna1b	Calcium channel, voltage- dependent, N type, alpha 1B subunit	NM_007579	Coppola et al., 1994	GABA	pre	0.743	0.005
	Gabra2	Gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	NM_008066	Buckle et al., 1989	GABA	post	0.878	0.037
	Gabrg1	Gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	NM_010252	Wilcox et al., 1992	GABA	post	0.768	0.010
	Gnai1	Guanine nucleotide binding protein (G protein), alpha inhibiting 1	NM_010305	Sullivan et al., 1986	GABA, glutamate	NA	0.788	0.033
	Itpr1	Inositol 1,4,5-trisphosphate receptor 1	NM_010585	Maeda et al., 1988	GABA	NA	0.684	0.016
gp120 METH vs. WT METH (ctl)	Adora1	Adenosine A1 receptor	NM_001008533	Johansson et al., 2001	GABA, glutamate	pre and post	0.730	0.027
	Cdk5r1	Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	NM_009871	Tsai et al., 1994	glutamate	NA	0.726	0.020
	Gria1	Glutamate receptor, ionotropic, AMPA1 (alpha 1)	NM_008165	Puckett et al., 1991	glutamate	post	0.868	0.025
	Grik5	Glutamate receptor, ionotropic, kainate 5 (gamma 2)	NM_010350	Szpirer et al., 1994	glutamate	post	0.429	0.00007
	Nsf	N-ethylmaleimide sensitive fusion protein	NM_008740	Block et al., 1988	GABA, glutamate	pre	0.854	0.026
	Slc17a7/ Vglut1	Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; vesicular glutamate transporter 1	NM_182993	Takamori et al., 2000 Bellocchio et al., 2000	glutamate	pre	0.697	0.014
gp120 SAL vs. WT METH (ctl)	Cdk5r1	Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	NM_009871	Tsai et al., 1994	glutamate	NA	1.146	0.031
	Slc1a3/ Eaat1/ Glast	Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6, EAAT1, GLAST	NM_009200	Takai et al., 1995	glutamate	NA	0.837	0.049
	Slc7a11	Solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	NM_011990	Sato et al., 1999	glutamate	NA	0.438	0.035
gp120 METH vs. gp120 SAL (ctl)	Gnai1	Guanine nucleotide binding protein (G protein), alpha inhibiting 1	NM_010305	Sullivan et al., 1986	GABA and glutamate	NA	0.836	0.034
	Gria3	Glutamate receptor, ionotropic, AMPA3 (alpha 3)	NM_016886	Sato et al., 1993	glutamate	post	0.880	0.017

Differentially regulated genes in brains of METH-treated gp120tg and WT mice and vehicle-treated gp120tg mice. List of 20 genes that were found to be significantly differentially regulated using a GABA and glutamate RT² Profiler PCR Array. The following information is provided: experimental group (ctl = control condition in the given comparison) abbreviated and full gene name, sequence number in GenBank, references, indication to which neurotransmitter system the gene belongs, synaptic localization (if applicable), fold change (ctl condition = 1) and p-values for the respective comparisons.