Figure 5.
MTSEA increases open probability in TRPV1 in the absence of capsaicin. (a) Channel openings in the absence of agonist in an inside-out membrane patch. (b) Macroscopic currents induced by MTSEA (blue trace) and capsaicin (4 µM) after MTSEA (black trace) in the same patch as in a. The number of channels in the patch was ~133.