Table 8.
Transcripts That Are Significantly Differentially Expressed 2-Fold or Greater in Ifng−/− Mice Reconstituted with Wild-Type Bone Marrow Compared with Ifng−/− Bone Marrow–Reconstituted in Both High-Dose and Low-Dose Streptococcus pneumoniae Pneumonia
| Gene Symbol* | Description | High-Dose SP |
Low-Dose SP |
||||
|---|---|---|---|---|---|---|---|
| SP/PBS Fold Change in WT BM Mice | SP/PBS Fold Change in Ifng−/− BM Mice | Fold Change in WT BM Mice with SP Compared with Ifng−/− BM Mice with SP | SP/PBS Fold Change in WT BM Mice | SP/PBS Fold Change in Ifng−/− BM Mice | Fold Change in WT BM Mice with SP Compared with Ifng−/− BM Mice with SP | ||
| Apol10b | Apolipoprotein L 10B [Source:MGI Symbol;Acc:MGI:3043522] | 3.7 | 1.5 | 3.3 | 3.7 | 1.2 | 4.0 |
| Apol6 | Apolipoprotein L 6 [Source:MGI Symbol;Acc:MGI:1919189] | 4.1 | 1.6 | 2.8 | 5.1 | 1.3 | 4.2 |
| Batf2 | Basic leucine zipper transcription factor, ATF-like 2 [Source:MGI Symbol;Acc:MGI:192173 | 8.3 | 2.9 | 2.6 | 7.9 | 2.1 | 3.4 |
| BC023105 | cDNA sequence BC023105 [Source:MGI Symbol;Acc:MGI:2384767] | 8.9 | 3.8 | 2.9 | 10.0 | 4.3 | 3.0 |
| Ciita | Class II transactivator [Source:MGI Symbol;Acc:MGI:108445] | 1.4 | −1.9 | 2.4 | 2.1 | −1.4 | 2.5 |
| Cxcl9 | Chemokine (C-X-C motif) ligand 9 [Source:MGI Symbol;Acc:MGI:1352449] | 28.9 | 21.6 | 3.3 | 32.1 | 18.2 | 4.3 |
| Fam26f | Family with sequence similarity 26, member F [Source:MGI Symbol;Acc:MGI:2443082] | 12.9 | 3.2 | 3.7 | 10.9 | 2.2 | 4.6 |
| Gbp10 | Guanylate-binding protein 10 [Source:MGI Symbol;Acc:MGI:4359647] | 7.4 | 3.1 | 3.1 | 8.2 | 2.8 | 3.8 |
| Gbp11 | Guanylate binding protein 11 [Source:MGI Symbol;Acc:MGI:3646307] | 10.0 | 4.2 | 3.0 | 13.0 | 3.0 | 5.4 |
| Gbp4 | Guanylate binding protein 4 [Source:MGI Symbol;Acc:MGI:97072] | 4.1 | 2.1 | 3.1 | 4.8 | 1.9 | 4.2 |
| Gm12185 | Predicted gene 12,185 [Source:MGI Symbol;Acc:MGI:3652173] | 5.7 | 2.5 | 2.5 | 4.4 | 2.0 | 2.4 |
| Gm12250 | Predicted gene 12,250 [Source:MGI Symbol;Acc:MGI:3649299] | 20.5 | 12.8 | 2.2 | 18.8 | 11.1 | 2.3 |
| Gm22079 | Predicted gene, 22,079 [Source:MGI Symbol;Acc:MGI:5451856] | 3.1 | 1.1 | 2.9 | 3.7 | 1.4 | 2.6 |
| Gm4841 | Predicted gene 4,841 [Source:MGI Symbol;Acc:MGI:3643814] | 10.0 | 2.8 | 3.8 | 14.4 | 3.4 | 4.4 |
| Ido1 | Indoleamine 2,3-dioxygenase 1 [Source:MGI Symbol;Acc:MGI:96416] | 10.5 | 1.6 | 7.6 | 12.9 | 1.5 | 10.2 |
| Igtp | IFN-γ–induced GTPase [Source:MGI Symbol;Acc:MGI:107729] | 7.3 | 4.5 | 2.1 | 7.7 | 4.3 | 2.3 |
| Irf1 | IFN regulatory factor 1 [Source:MGI Symbol;Acc:MGI:96590] | 4.1 | 2.0 | 2.2 | 4.0 | 1.6 | 2.8 |
| Pydc3 | Pyrin domain containing 3 | 6.0 | −1.0 | 7.4 | 3.8 | −1.0 | 4.7 |
| Slamf8 | SLAM family member 8 [Source:MGI Symbol;Acc:MGI:1921998] | 6.7 | 1.7 | 3.2 | 9.7 | 2.6 | 3.0 |
| Socs1 | Suppressor of cytokine signaling 1 [Source:MGI Symbol;Acc:MGI:1354910] | 13.4 | 6.4 | 2.3 | 11.1 | 5.0 | 2.4 |
| Tgtp1 | T cell–specific GTPase 1 [Source:MGI Symbol;Acc:MGI:98734] | 10.9 | 2.0 | 5.7 | 11.5 | 2.1 | 5.7 |
| Tgtp2 | T cell–specific GTPase 2 [Source:MGI Symbol;Acc:MGI:3710083] | 13.0 | 7.4 | 2.8 | 13.9 | 5.9 | 3.7 |
Definition of abbreviations: BM, bone marrow; SP, S. pneumonia; WT, wild type.
*
Genes that have been previously described in the literature as IFN-γ regulated are shown in bold.