Table 1.
SNP,* Group | Subjects with Genotype (n [%]) |
Genotypic Comparison |
HWE P Value | |||
---|---|---|---|---|---|---|
00 | 01 | 11 | χ2 | P Value | ||
rs11859842 T/C | ||||||
Control | 364 (0.953) | 18 (0.047) | 0 (0) | 0.637 | ||
All TB† | 347 (0.934) | 21 (0.061) | 2 (0.006) | 2.883 | 0.237 | |
rs11150564 G/A | ||||||
Control | 218 (0.578) | 137 (0.363) | 22 (0.058) | 0.938 | ||
All TB | 196 (0.578) | 116 (0.342) | 27 (0.080) | 1.410 | 0.494 | |
rs4788172 G/A | ||||||
Control | 126 (0.335) | 187 (0.497) | 63 (0.168) | 0.650 | ||
All TB | 122 (0.378) | 123 (0.381) | 78 (0.241) | 10.92 | 0.004 | |
rs3764275 C/A | ||||||
Control | 163 (0.429) | 176 (0.463) | 41 (0.108) | 0.523 | ||
All TB | 161 (0.491) | 126 (0.384) | 41 (0.125) | 4.496 | 0.106 | |
rs11574552 T/C | ||||||
Control | 171 (0.451) | 165 (0.476) | 43 (0.113) | 0.738 | ||
All TB | 143 (0.427) | 133 (0.397) | 59 (0.176) | 5.753 | 0.056 | |
rs3764276 T/C | ||||||
Control | 381 (0.997) | 1 (0.003) | 0 (0) | 0.980 | ||
All TB | 348 (0.997) | 1 (0.003) | 0 (0) | 0.004 | 0.949 | |
rs2071420 A/G | ||||||
Control | 179 (0.469) | 165 (0.432) | 38 (0.099) | 0.998 | ||
All TB | 154 (0.467) | 132 (0.400) | 44 (0.133) | 2.197 | 0.333 | |
rs1050881 C/T | ||||||
Control | 161 (0.429) | 172 (0.459) | 42 (0.112) | 0.698 | ||
All TB | 146 (0.465) | 119 (0.379) | 49 (0.156) | 5.567 | 0.062 | |
rs17842268 T/C | ||||||
Control | 165 (0.440) | 176 (0.469) | 34 (0.091) | 0.181 | ||
All TB | 161 (0.407) | 127 (0.371) | 54 (0.158) | 11.02 | 0.004 | |
rs12596308 T/C | ||||||
Control | 156 (0.413) | 180 (0.476) | 42 (0.111) | 0.354 | ||
All TB | 137 (0.408) | 132 (0.393) | 67 (0.199) | 11.92 | 0.003 | |
rs12599318 G/A | ||||||
Control | 361 (0.953) | 18 (0.047) | 0 (0) | 0.636 | ||
All TB | 315 (0.938) | 19 (0.057) | 2 (0.057) | 2.581 | 0.275 |
Definition of abbreviations: HWE, Hardy Weinberg equilibrium P value in control subjects; SNP, single-nucteotide polymorphism; TB, tuberculosis.
SNPs are listed by reference SNP ID in genomic order on chromosome 16. 0, common allele; 1, minor allele.
All TB includes pulmonary tuberculosis and tuberculous meningitis cases from the discovery cohort.