Table 2.
CD43 Polymorphisms, Genetic Models, and Tuberculosis Phenotypes
| SNP* | Group | Subjects with Genotype (n [%]) |
Genotypic Model |
Recessive Model |
Dominant Model |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 00 | 01 | 11 | χ2 | P value | OR | 95% CI | P value | OR | 95% CI | P value | ||
| rs4788172 | Control | 126 (0.335) | 187 (0.497) | 63 (0.168) | ||||||||
| G/A | All TB | 122 (0.378) | 123 (0.381) | 78 (0.241) | 10.92 | 0.004 | 1.58 | 1.09–2.29 | 0.015 | 1.38 | 0.88–1.64 | 0.241 |
| PTB | 58 (0.341) | 72 (0.424) | 40 (0.235) | 4.21 | 0.122 | 1.53 | 0.98–2.39 | 0.061 | 0.02 | 0.70–1.51 | 0.889 | |
| TBM | 64 (0.418) | 51 (0.333) | 38 (0.248) | 12.32 | 0.002 | 1.64 | 1.04–2.59 | 0.032 | 2.80 | 0.97–2.10 | 0.094 | |
| rs17842268 | Control | 165 (0.440) | 176 (0.469) | 34 (0.091) | ||||||||
| T/C | All TB | 161 (0.471) | 127 (0.371) | 54 (0.158) | 11.02 | 0.004 | 1.88 | 1.34–2.63 | 0.006 | 0.68 | 0.94–1.36 | 0.409 |
| PTB | 85 (0.470) | 71 (0.392) | 25 (0.138) | 4.46 | 0.107 | 1.61 | 0.93–2.79 | 0.088 | 0.43 | 0.79–1.61 | 0.511 | |
| TBM | 76 (0.472) | 56 (0.348) | 29 (0.180) | 11.77 | 0.003 | 2.20 | 1.29–3.76 | 0.003 | 0.37 | 0.79–1.65 | 0.542 | |
| rs12596308 | Control | 156 (0.413) | 180 (0.476) | 42 (0.111) | ||||||||
| T/C | All TB | 137 (0.408) | 132 (0.393) | 67 (0.199) | 11.92 | 0.003 | 1.99 | 1.48–2.69 | 0.001 | 0.01 | 1.60–2.43 | 0.893 |
| PTB | 69 (0.394) | 76 (0.434) | 30 (0.171) | 3.90 | 0.143 | 1.65 | 1.00–2.75 | 0.049 | 0.17 | 0.64–1.34 | 0.682 | |
| TBM | 68 (0.422) | 56 (0.348) | 37 (0.230) | 15.13 | 0.001 | 2.39 | 1.47–3.89 | <0.001 | 1.04 | 0.72–1.51 | 0.835 | |
Definition of abbreviations: CI, confidence interval; OR, odds ratio; PTB, pulmonary tuberculosis; SNP, single-nucteotide polymorphism; TB, tuberculosis; TBM, tuberculous meningitis.
*
SNPs are listed by reference SNP ID. For OR calculations, each group was compared with the control group. 0, common allele; 1, minor frequency allele.