Table 3.
CD43 Single-Nucleotide Polymorphisms and Tuberculous Meningitis Disease Presentation
| SNP | Unadjusted Model |
Adjusted for Age and Gender |
||||
|---|---|---|---|---|---|---|
| OR* | 95% CI | P Value | OR | 95% CI | P Value | |
| rs4788172 G/A, n = 147 | ||||||
| TBM grade | 1.49 | 1.04–2.12 | 0.03 | 1.19 | 0.81–1.77 | 0.37 |
| Glasgow coma scale | 1.74 | 1.17–2.60 | 0.01 | 1.53 | 0.99–2.37 | 0.06 |
| Focal deficit | 0.91 | 0.47–1.75 | 0.77 | 0.91 | 0.47–1.77 | 0.78 |
| rs17842268 T/C, n = 155 | ||||||
| TBM grade | 1.72 | 1.05–2.81 | 0.03 | 1.33 | 0.76–2.33 | 0.32 |
| Glasgow coma scale | 1.49 | 0.92–2.43 | 0.11 | 1.01 | 0.59–1.74 | 0.96 |
| Focal deficit | 4.02 | 1.58–10.2 | 0.004 | 4.46 | 1.71–11.6 | 0.002 |
| rs12596308 T/C, n = 100 | ||||||
| TBM grade | 1.65 | 1.02–2.68 | 0.04 | 1.39 | 0.77–2.33 | 0.31 |
| Glasgow coma scale | 1.46 | 0.91–2.36 | 0.12 | 0.99 | 0.58–1.71 | 0.98 |
| Focal deficit | 2.34 | 0.99–5.50 | 0.05 | 2.59 | 1.06–6.33 | 0.04 |
Definition of abbreviations: CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; TBM, tuberculous meningitis.
*
Odds ratio estimated following recessive model.