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. 2015 Mar;52(3):332–341. doi: 10.1165/rcmb.2014-0141OC

Figure 3.

Figure 3.

Effect of small interfering RNA (siRNA)-mediated suppression of CD38 expression on Ang II–induced Ca2+ release (AICR) in PASMCs. (A) An immunoblot of CD38 from samples of PASMCs transfected with a CD38-targeting siRNA and a control scrambled sequence. (B) The mean CD38 protein levels from the two groups after normalization with β-actin (n = 5). *Significant decrease in expression compared with the scrambled control (P = 0.006). (C) The mean traces of AICR in the control scrambled sequence and CD38 siRNA–transfected PASMCs in the absence or presence of 20 mM NA. (D) The mean peak Δ[Ca2+]i in the control scrambled sequence and CD38 siRNA–transfected PASMCs in the absence or presence of 20 mM NA (n = 8 for each group). *Significant difference from the control group in the absence of NA. n.s., no significant difference between the groups indicated.