Table 4.

Genome-Wide Association Study Meta-Analysis Results of Subjects with Chronic Obstructive Pulmonary Disease with a Pulmonary Artery:Ascending Aorta Ratio Greater Than 1 versus Smoking Control Subjects Compared with Those of Subjects with Chronic Obstructive Pulmonary Disease with a Pulmonary Artery:Ascending Aorta Ratio of 1 or Less versus Smoking Control Subjects for Previously Identified COPD Risk Alleles

Locus	Gene	SNP	Risk Allele	COPD with PA/A > 1 versus Smoking Control Subjects		COPD with PA/A ≤ 1 versus Smoking Control Subjects		Permutation Testing to Assess Difference of OR between Two Meta-Analyses, 10,000 Times
				OR	P Value	OR	P Value	P Value
4q22	FAM13A	rs2869967*	C	1.25	9.14 × 10−5	1.28	8.73 × 10−10	NS
4q22	FAM13A	rs4416442†	C	1.27	1.66 × 10−5	1.28	1.74 × 10−10	NS
4q22	FAM13A	rs7671167*,‡	T	1.25	7.39 × 10−5	1.22	2.32 × 10−7	NS
4q22	FAM13A	rs1964516‡	T	1.17	6.32 × 10−3	1.23	2.38 × 10−7	0.015
4q31	HHIP	rs13141641†,‡	T	1.28	5.68 × 10−5	1.23	7.94 × 10−7	0.013
4q31	HHIP	rs13118928‡	A	1.22	9.25 × 10−4	1.21	4.25 × 10−6	NS
15q25	CHRNA3	rs12914385†	T	1.36	1.61 × 10−7	1.23	5.98 × 10−7	<0.0001
15q25	AGPHD1	rs8034191§	C	1.40	7.80 × 10−9	1.12	7.97 × 10−3	<0.0001
15q25	IREB2	rs11858836‡	A	1.38	3.90 × 10−7	1.16	1.32 × 10−3	<0.0001
19q13	RAB4B	rs2604894‡	G	1.16	1.01 × 10−2	1.10	1.53 × 10−2	0.010
14q32	RIN3	rs754388†	C	1.38	3.49 × 10−5	1.29	1.19 × 10−6	0.007
14q32	RIN3	rs17184313†	C	1.27	2.15 × 10−3	1.27	8.53 × 10−6	NS

Definition of abbreviations: COPD, chronic obstructive pulmonary disease; NS, not significant; OR, odds ratio; PA/A, ratio of the diameter of the main pulmonary artery (PA) at the level of its bifurcation and the diameter of the ascending aorta (A) in its maximum dimension measured by computed tomography; SNP, single-nucleotide polymorphism.

^*Cho and colleagues (Ref. 27).

^†Cho and colleagues (Ref. 23).

^‡Cho and colleagues (Ref. 29).

^§Pillai and colleagues (Ref. 37).