Table 2.

Comparison of Early (≤ 7 days) vs. Late (> 7 days) Onset of NEC.

Factor	Total Cohort n = 39	Early n = 28	Late n = 11	P
EGA (weeks)	39 (38, 40)	39 (38, 40)	39 (37, 40)	0.33
Male gender	24 (62%)	18 (64%)	6 (55%)	0.72
Birth Weight (kg)	3.17 ± 0.59	3.13 ± 0.56	3.26 ± 0.67	0.56
Age at NEC onset (days)	8.7 ± 12.8	2.5 ± 1.6	26.9 ± 14.0	<0.001
C-Section Delivery	12 (31%)	8 (29%)	4 (36%)	0.69
APGAR at 0 min	8 (8, 9)	8 (8, 9)	7 (4, 8)	0.10
APGAR at 5 min	9 (8, 9)	9 (9, 9)	8 (5, 8)	0.01
Congenital Heart Disease	9 (23%)	5 (17%)	4 (40%)	0.24
Hypoxic event	11 (28%)	7 (25%)	4 (36%)	1.0
Perinatal sepsis	25 (64%)	16 (57%)	9 (82%)	0.27
Maternal factors	15 (38%)	12 (43%)	3 (27%)	0.48
Congenital Anomalies	12 (31%)	6 (21%)	6 (55%)	0.06
Genetic Anomalies	7 (18%)	2 (7%)	5 (46%)	0.01
UA Catheter placed	5 (13%)	2 (7%)	3 (27%)	0.13
Formula feeds only	25 (64%)	19 (73%)	6 (55%)	0.44
Medical Management	15 (38%)	8 (29%)	7 (64%)	0.07
Bell’s II NEC	21 (54%)	16 (57%)	5 (46%)	0.72
Bell’s III NEC	18 (46%)	12 (43%)	6 (55%)	0.72
OR prior to NEC	4 (10%)	0 (0%)	4 (36%)	0.004
Length of NICU stay	29.5 (21, 60)	26.5 (20.8, 60.5)	40 (20.5, 60)	0.66
Mortality	7 (18%)	3 (11%)	4 (36%)	0.08
	OR	Lower CI	Upper CI	P
Multivariable Analysis of Factors Associated with Late Onset NEC
APGAR at 5 min	0.58	0.31	1.1	0.09
Mortality	90.8	2.6	3121	0.01

P value for early vs. late onset of NEC.

Mean ± standard deviation.

Median (interquartile range).

N (percentage).