FIGURE 1:

Representative 3D micro-CT reconstruction (top) and quantification (bottom-left) of the cortical microvascular (MV) density (<200 µm in diameter), renal MV media-to-lumen ratio (bottom-middle) and renal expression of plasminogen (Plg) and tissue-transglutaminase (tTg) by western blot (bottom-right) from stenotic kidneys of normal, RVD and RVD + macitentan-treated animals at 10 weeks. Macitentan improved cortical MV density but not MV media-to-lumen ratio or the renal expression of Plg and tTg, indicating persistence of some MV damage in the stenotic kidney (*P < 0.05 versus normal, ^†P < 0.05 versus RVD).