FIGURE 2:

Renal protein expression (top, n = 4–5 per group, two representative bands per animal shown) and average quantification per group (bottom) of VEGF, p-Akt, Ang-1, angiostatin and endostatin in normal, RVD and RVD + macitentan pigs. Macitentan partly improved the angiogenic cascade in the stenotic kidney after 4 weeks of treatment (*P < 0.05 versus normal, ^†P < 0.05 versus RVD).