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Representative pictures (trichrome) of the glomeruli (top) and tubulointerstitium (middle) and average quantification per group of renal morphometric analysis and apoptosis (bottom) of normal, RVD and RVD + macitentan. Four weeks of macitentan treatment reduced renal apoptosis and fibrosis in the stenotic kidney. (*P < 0.05 versus normal, †P < 0.05 versus RVD).
