Table 1.
Body weight, mean arterial pressure, degree of stenosis, SCr and basal parameters of single-kidney hemodynamics and function (mean ±SEM), after 6 weeks of RVD but before treatment with macitentan in normal, RVD and RVD pigs before macitentan treatment (RVD +macitentan)
| Parameter | Normal, n = 7 | RVD, n = 7 | RVD before macitentan, n = 6 |
|---|---|---|---|
| Body weight (kg) | 53.3 ± 1.7 | 45.7 ± 1.5* | 45 ± 4.2 |
| Mean arterial pressure (mmHg) | 100.8 ± 7.2 | 151.2 ± 10.7* | 147.4 ± 10.9* |
| Degree of stenosis (%) | 0.00 | 72.7 ± 6.8 | 71.2 ± 8.3 |
| SCr (μmol/L) | 74.7 ± 4.8 | 94.1 ± 7.78* | 95 ± 8.3* |
| Albuminuria (μg/mL) | 2.50 ± 1.21 | 134.68 ± 46.4* | 104.81 ± 60.5* |
| Renal vascular resistance (mmHg/mL/min) | 0.17 ± 0.02 | 0.58 ± 0.17* | 0.61 ± 0.2* |
| Renal volume (cc) | |||
| Cortex | 123.3 ± 7.1 | 62.6 ± 6.2* | 67.4 ± 3.9* |
| Medulla | 35.1 ± 2.5 | 18.4 ± 2.8* | 17.9 ± 2.9* |
| RBF (mL/min) | 589.9 ± 32.5 | 260.8 ± 59.9* | 242.9 ± 41.8* |
| Perfusion (mL/min/cc) | |||
| Cortex | 4.5 ± 0.7 | 3.2 ± 0.6 | 3.1 ± 0.5 |
| Medulla | 2.3 ± 0.4 | 2.4 ± 0.6 | 1.7 ± 0.4 |
| GFR (mL/min) | 65.9 ± 9.0 | 34.8 ± 8.1* | 42.3 ± 4.4* |
*P ≤ 0.05 versus normal.