Table 2.
Body weight, mean arterial pressure, degree of stenosis, plasmin rennin activity, circulating endothelin-1, serum creatinine and basal parameters of single-kidney hemodynamics and functions (mean ± SEM) after 10 weeks of RVD, for normal, RVD and RVD pigs after 4 weeks of macitentan treatment (RVD + macitentan)
| Parameter | Normal, n = 7 | RVD, n = 7 | RVD + macitentan, n = 6 |
|---|---|---|---|
| Body weight (kg) | 52.6 ± 2.5 | 54.6 ± 3.5 | 52.8 ± 3.8 |
| Mean arterial pressure (mmHg) | 101.4 ± 5.5 | 145.1 ± 10.4 | 147.2 ± 13.6 |
| Degree of stenosis (%) | 0.00 | 72.5 ± 8.1 | 77.9 ± 6.3 |
| PRA (ng/mL/h) | 0.19 ± 0.01 | 0.22 ± 0.04 | 0.21 ± 0.03 |
| ET-1 (pg/mL) | 0.64 ± 0.01 | 0.83 ± 0.08* | 1.1 ± 0.03*,† |
| SCr (μmol/L) | 88.5 ± 14.8 | 125.2 ± 4.2* | 121.0 ± 22.3* |
| Albuminuria (μg/mL) | 2.98 ± 1.12 | 130.2 ± 48.6 | 4.46 ± 4.24†,‡ |
| Renal vascular resistance (mmHg/mL/min) | 0.19 ± 0.02 | 0.49 ± 0.1* | 0.46 ± 0.2* |
| Renal volume (cc) | |||
| Cortex | 110.9 ± 4.78 | 64.7 ± 9.9* | 84.7 ± 4.3*,† |
| Medulla | 33.7 ± 0.8 | 19.2 ± 4.5* | 26.3 ± 3.7* |
| RBF (mL/min) | 530.5 ± 26.6 | 291.7 ± 74.7* | 313.8 ± 36.4*,^ |
| Perfusion (mL/min/cc) | |||
| Cortex | 4.3 ± 0.3 | 3.6 ± 0.7 | 3.3 ± 0.4 |
| Medulla | 1.7 ± 0.3 | 1.8 ± 0.6 | 1.6 ± 0.2 |
| GFR (mL/min) | 73.8 ± 6.4 | 44.3 ± 6.8* | 40.0 ± 6.4* |
*P < 0.05 versus normal.
†P < 0.05 versus RVD.
‡P < 0.05 versus 6 weeks.
^P = 0.06 versus 6 weeks.