Table 3.
Summary of studies reported effect of biocompatible peritoneal solution on RRF
| Reference (year) | Study design | Subject characteristics | Favour balance solution | Details |
|---|---|---|---|---|
| Feriani et al. (1998) [76] | 6-month randomized controlled trial | Prevalent 33 lactate base, 36 bicarbonate base | No | |
| Coles et al. (1998) [77] | 2-month randomized controlled trial | Prevalent 3 arms, 19 lactate base, 20 lactate/bicarbonate, 20 bicarbonate | No | |
| Tranaeus et al. (2000) [78] | 1-year randomized controlled trial | Prevalence 106 CAPD, 70 (bicarbonate/lactate), 36 (lactate) | No | |
| Rippe et al. (2001) [69] | 2-year randomized controlled trial | Prevalent 40 conventional, 40 neutral pH dialysate | No | |
| Williams et al. (2004) [66] | 6-month randomized crossover | Prevalent 86 CAPD subjects | Yes | Renal CrCl and urea clearance increase when using balance solution and decrease when using standard solution |
| Montenegro et al. (2006) [79] | 1-year randomized controlled trial | Incident 36 CAPD, 18 (lactate base), 18 (bicarbonate base) | Yes | GFR decline in lactate base group, but preserved in bicarbonate group |
| Szeto et al. (2007) [70] | 1-year randomized controlled trial | Incident 25 conventional, 25 neutral | No | |
| Fan et al. (2008) [71] | 1-year randomized controlled trial | Incident 61 CAPD or APD for conventional fluid, 57 CAPD or APD for neutral fluid | No | |
| Choi et al. (2008) [74] | 1-year randomized controlled trial | Prevalent, 104 CAPD, 51(neutral), 53 (conventional) | No | |
| Weiss et al. (2009) [80] | 6-month prospective crossover | Prevalent 53 CAPD | Yes | Improvement of GFR when using bicarbonate base solution |
| Pajek et al. (2009) [74] | 6-month prospective crossover | Prevalent 26 CAPD | No | |
| Haag-Weber et al. (2010) [81] | 18-month randomized controlled | Prevalent 69 CAPD, 43 (neutral), 26 (conventional) | Yes | Monthly RRF change faster in conventional group, −4.3% versus −1.5% (P = 0.04) |
| Bajo et al. (2011) [72] | 2-year prospective | Incident 20 standard, 13 balance fluid | No | |
| Johnson et al. (2012) [73] | 2-year randomized controlled trial | Incident 93 conventional, 92 balance fluid | No | |
| Kim et al. (2012) [82] | 2-year randomized controlled trial | Incident 91 CAPD, 48 (balance), 43 (conventional) | Yes | Residual renal function significantly higher in balance solution at the end of study |
| Cho et al. (2013) [76] | 1-year randomized controlled trial | Incident CAPD, 32 (balance), 28 (conventional) | No |