Table 4.
Plasma phospholipid n-3 FAs modify the association between incident type 2 diabetes and serum NEFAs, presented as HRs (95% CIs), MESA, N = 5,697
| Quartiles of NEFAs | Ptrend | ||||
|---|---|---|---|---|---|
| Quartile, n | 1 (n = 1,380) | 2 (n = 1,461) | 3 (n = 1,455) | 4 (n = 1,401) | |
| Range | 0.13–0.39 | 0.40–0.52 | 0.53–0.67 | 0.68–2.11 | |
| Pinteraction = 0.03 | |||||
| Low n-3 (<75th percentile)* | |||||
| Cases, n | 92 | 127 | 147 | 157 | |
| Model 1, HR (95% CI) | 1.0 | 1.41 (1.07, 1.84) | 1.77 (1.35, 2.31) | 2.18 (1.65, 2.88) | <0.001 |
| Model 2, HR (95% CI) | 1.0 | 1.30 (1.00, 1.70) | 1.51 (1.15, 1.98) | 1.83 (1.39, 2.43) | <0.001 |
| High n-3 (≥75th percentile)* | |||||
| Cases, n | 32 | 39 | 34 | 29 | |
| Model 1, HR (95% CI) | 1.0 | 1.17 (0.72, 1.89) | 1.01 (0.60, 1.70) | 0.96 (0.55, 1.66) | 0.85 |
| Model 2, HR (95% CI) | 1.0 | 1.00 (0.61, 1.63) | 0.89 (0.53, 1.51) | 0.80 (0.46, 1.40) | 0.83 |
Model 1 adjusted for age, sex, race, education, field center, smoking, and alcohol use. Model 2 adjusted for model 1 plus waist circumference and hs-CRP.
*Low n-3 FA category <75th percentile; high n-3 FA category ≥75th percentile.