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. 2015 Mar 23;10(3):e0119142. doi: 10.1371/journal.pone.0119142

Fig 2. Dicer suppression induces alterations in renal morphology and function.

Fig 2

Morphology of the kidneys in control (Ctr) and heterozygous (Het) or homozygous (cKO) Dicer cKO mice at P30 and P50 and their relative kidney (KW) and body (BW) weight. Panel A shows kidneys at P30 have a smaller size in cKO mice compared to the other group. This is correlated with low BW (similar KW/BW). In panel B, at P50, the kidneys of the Dicer cKO mice have a rough and pale structure compared to the other groups. Differences in KW/BW ratio in cKO mice suggest that the development of renal failure is coupled with morphological alteration. Heterozygous mice (Het) do not show any differences from Ctr mice. Panel C shows the glomerular filtration rate (GFR) measured by the clearance of inulin (left) and the urinary protein abundance in a 24h collection (right). At P50, cKO mice present a significantly altered GFR and proteinuria compared to Ctr. Data are expressed as mean ± sem; n power is expressed in brackets.