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. 2015 Mar 23;10(3):e0121338. doi: 10.1371/journal.pone.0121338

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© 2015 Gao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 6 — (A): The mice tumors’ volume in different groups. After six weeks of treatment, digoxin therapy decreased the tumors’ volume, which was significantly smaller than those in the saline control group (p<0.05). (B): IHC results in different groups. Additionally, the IHC results confirmed the effect of digoxin: Digoxin therapy decreased the HIF-lα and SCF positive tumor cells compared to the saline control group, respectively.