Table 3.
Modeled median ± SE biomarker concentrations by quintile of average AHEI score from 1984–1990 for 1922 women
| AHEI Dietary Pattern Score
|
||||||
|---|---|---|---|---|---|---|
| Q1 (11–32) | Q2 (33–37) | Q3 (38–42) | Q4 (43–48) | Q5 (49–72) | P for trend1 | |
| Total Adiponectin (μg/mL) | ||||||
| Model 12 | 12.61 ± 1.033 | 13.18 ± 1.03 | 13.36 ± 1.03 | 14.08 ± 1.03 | 15.68 ± 1.03 | <0.0001 |
| Model 24 | 12.79 ± 1.03 | 13.15 ± 1.03 | 13.31 ± 1.03 | 13.96 ± 1.03 | 15.36 ± 1.03 | <0.0001 |
| Model 35 | 11.69 ± 1.03 | 12.11 ± 1.03 | 12.01 ± 1.03 | 12.40 ± 1.03 | 13.33 ± 1.03 | 0.0004 |
| Model 3 + all other significant biomarkers6 | 11.54 ± 1.04 | 12.05 ± 1.04 | 12.06 ± 1.04 | 12.52 ± 1.04 | 12.88 ± 1.04 | 0.04 |
| HMW Adiponectin (μg/mL) | ||||||
| Model 1 | 4.34 ± 1.04 | 4.41 ± 1.04 | 4.59 ± 1.04 | 5.01 ± 1.04 | 5.71 ± 1.04 | <0.0001 |
| Model 2 | 4.46 ± 1.04 | 4.40 ± 1.05 | 4.55 ± 1.04 | 4.96 ± 1.04 | 5.53 ± 1.05 | <0.0001 |
| Model 3 | 3.82 ± 1.04 | 3.82 ± 1.04 | 3.82 ± 1.04 | 4.07 ± 1.04 | 4.37 ± 1.05 | 0.004 |
| Model 3 + all other significant biomarkers | 3.81 ± 1.06 | 3.70 ± 1.06 | 3.81 ± 1.06 | 4.08 ± 1.06 | 4.11 ± 1.06 | 0.13 |
| Resistin (ng/mL) | ||||||
| Model 1 | 18.06 ± 1.03 | 17.51 ± 1.03 | 16.24 ± 1.03 | 16.62 ± 1.03 | 15.19 ± 1.03 | <0.0001 |
| Model 2 | 18.08 ± 1.03 | 17.85 ± 1.03 | 16.69 ± 1.03 | 17.16 ± 1.03 | 15.90 ± 1.03 | 0.0002 |
| Model 3 | 19.41 ± 1.03 | 19.02 ± 1.03 | 18.07 ± 1.03 | 18.63 ± 1.03 | 17.54 ± 1.03 | 0.01 |
| Model 3 + all other significant biomarkers | 18.82 ± 1.04 | 17.55 ± 1.04 | 16.90 ± 1.04 | 18.85 ± 1.04 | 16.39 ± 1.04 | 0.01 |
| sTNF-αRII (pg/mL) | ||||||
| Model 1 | 2643 ± 1.03 | 2496 ± 1.03 | 2432 ± 1.03 | 2405 ± 1.03 | 2376 ± 1.03 | 0.0008 |
| Model 2 | 2639 ± 1.03 | 2527 ± 1.03 | 2463 ± 1.03 | 2457 ± 1.03 | 2424 ± 1.03 | 0.008 |
| Model 3 | 2762 ± 1.03 | 2675 ± 1.03 | 2601 ± 1.03 | 2620 ± 1.03 | 2629 ± 1.03 | 0.10 |
| Interleukin-6 (ng/mL) | ||||||
| Model 1 | 2.40 ± 1.05 | 2.17 ± 1.05 | 2.34 ± 1.05 | 2.07 ± 1.05 | 1.88 ± 1.05 | 0.0003 |
| Model 2 | 2.37 ± 1.05 | 2.22 ± 1.06 | 2.39 ± 1.05 | 2.17 ± 1.06 | 1.97 ± 1.06 | 0.01 |
| Model 3 | 2.57 ± 1.05 | 2.47 ± 1.05 | 2.65 ± 1.05 | 2.45 ± 1.05 | 1.30 ± 1.06 | 0.17 |
| CRP (mg/dL) | ||||||
| Model 1 | 0.27 ± 1.08 | 0.25 ± 1.08 | 0.21 ± 1.08 | 0.24 ± 1.08 | 0.16 ± 1.08 | <0.0001 |
| Model 2 | 0.27 ± 1.08 | 0.26 ± 1.08 | 0.22 ± 1.08 | 0.25 ± 1.09 | 0.17 ± 1.09 | <0.0001 |
| Model 3 | 0.34 ± 1.08 | 0.35 ± 1.08 | 0.29 ± 1.08 | 0.36 ± 1.08 | 0.27 ± 1.08 | 0.02 |
| Model 3 + all other significant biomarkers | 0.32 ± 1.08 | 0.33 ± 1.08 | 0.26 ± 1.08 | 0.34 ± 1.08 | 0.27 ± 1.08 | 0.22 |
| sE-Selectin (ng/mL) | ||||||
| Model 1 | 57.60 ± 1.03 | 52.20 ± 1.03 | 52.92 ± 1.03 | 48.92 ± 1.03 | 46.57 ± 1.03 | <0.0001 |
| Model 2 | 57.28 ± 1.03 | 52.53 ± 1.04 | 53.50 ± 1.03 | 49.49 ± 1.03 | 47.01 ± 1.04 | <0.0001 |
| Model 3 | 61.42 ± 1.03 | 57.20 ± 1.03 | 58.36 ± 1.03 | 54.74 ± 1.03 | 53.61 ± 1.04 | 0.001 |
| Model 3 + all other significant biomarkers | 58.92 ± 1.03 | 54.56 ± 1.03 | 57.27 ± 1.03 | 53.98 ± 1.03 | 54.20 ± 1.03 | 0.08 |
| sICAM-1 (ng/mL) | ||||||
| Model 1 | 274 ± 1.02 | 260 ± 1.02 | 254 ± 1.02 | 261 ± 1.02 | 248 ± 1.02 | <0.0001 |
| Model 2 | 276 ± 1.02 | 269 ± 1.02 | 262 ± 1.02 | 273 ± 1.02 | 260 ± 1.02 | 0.03 |
| Model 3 | 281 ± 1.02 | 274 ± 1.02 | 268 ± 1.02 | 281 ± 1.02 | 269 ± 1.02 | 0.17 |
| sVCAM-1 (ng/mL) | ||||||
| Model 1 | 562 ± 1.02 | 558 ± 1.02 | 538 ± 1.02 | 518 ± 1.02 | 532 ± 1.02 | 0.01 |
| Model 2 | 554 ± 1.02 | 556 ± 1.02 | 536 ± 1.02 | 518 ± 1.02 | 529 ± 1.02 | 0.04 |
| Model 3 | 562 ± 1.02 | 566 ± 1.02 | 546 ± 1.02 | 529 ± 1.02 | 543 ± 1.02 | 0.14 |
| Ferritin (ng/mL) | ||||||
| Model 1 | 59.61 ± 1.07 | 70.05 ± 1.08 | 62.69 ± 1.07 | 54.27 ± 1.08 | 45.55 ± 1.07 | 0.0004 |
| Model 2 | 59.89 ± 1.07 | 70.99 ± 1.08 | 63.16 ± 1.07 | 54.72 ± 1.08 | 46.38 ± 1.08 | 0.001 |
| Model 3 | 62.09 ± 1.08 | 74.61 ± 1.08 | 65.83 ± 1.07 | 57.97 ± 1.08 | 50.59 ± 1.08 | 0.01 |
| Model 3 + all other significant biomarkers | 56.91 ± 1.08 | 68.64 ± 1.08 | 61.89 ± 1.07 | 55.11 ± 1.08 | 49.93 ± 1.08 | 0.08 |
| C-peptide (pmol/mL) | ||||||
| Model 1 | 0.75 ± 1.06 | 0.67 ± 1.07 | 0.67 ± 1.06 | 0.60 ± 1.07 | 0.53 ± 1.06 | <0.0001 |
| Model 2 | 0.74 ± 1.06 | 0.68 ± 1.07 | 0.67 ± 1.06 | 0.62 ± 1.07 | 0.55 ± 1.06 | 0.001 |
| Model 3 | 0.83 ± 1.06 | 0.81 ± 1.06 | 0.78 ± 1.06 | 0.76 ± 1.06 | 0.71 ± 1.06 | 0.06 |
| Insulin (uU/mL) | ||||||
| Model 1 | 11.29 ± 1.05 | 10.36 ± 1.06 | 10.58 ± 1.05 | 9.20 ± 1.05 | 8.90 ± 1.05 | <0.0001 |
| Model 2 | 10.92 ± 1.05 | 10.47 ± 1.06 | 10.73 ± 1.06 | 9.46 ± 1.06 | 9.16 ± 1.06 | 0.003 |
| Model 3 | 11.69 ± 1.05 | 11.56 ± 1.06 | 11.74 ± 1.06 | 10.52 ± 1.06 | 10.69 ± 1.06 | 0.10 |
| HbA1c (g/dL) | ||||||
| Model 1 | 0.61 ± 1.02 | 0.58 ± 1.02 | 0.56 ± 1.02 | 0.55 ± 1.02 | 0.55 ± 1.02 | 0.0002 |
| Model 2 | 0.60 ± 1.02 | 0.58 ± 1.03 | 0.56 ± 1.02 | 0.56 ± 1.03 | 0.55 ± 1.03 | 0.003 |
| Model 3 | 0.62 ± 1.02 | 0.60 ± 1.02 | 0.58 ± 1.02 | 0.58 ± 1.03 | 0.58 ± 1.03 | 0.07 |
1
P for trend from multivariate linear regression
2
Model 1: adjusted for caloric intake (quintiles) and age
3
Modeled median ± SE (all such values)
4
Model 2: Model 1 + adjustment for weekly physical activity (quintiles), and smoking status (never, former, current)
5
Model 3: Model 2 + adjustment for BMI
6
Model 3 + adjustment for all other biomarkers that were significantly associated with the AHEI in Model 3