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. 2015 Mar 23;10(3):e0120887. doi: 10.1371/journal.pone.0120887

Fig 5. New classification of UBZ family proteins.

Fig 5

The sequence of UBZs were aligned using ClustalW2. The sequences of NEMO- and Polη-UBZs were aligned, based on their three-dimensional structures. The sequences were then divided according to the presence of Ub-binding residues. The Ub-binding residues related to FAAP20-UBZ are highlighted in red, while those related to WRNIP1-UBZ and Rad18-UBZ are highlighted in black. The zinc-ion-coordinating residues are highlighted in blue. Black and red arrows indicate the positions of WRNIP1 Pro21 and Val22 and FAAP20 Leu167 and Ala168, respectively.