Table 1. Physicochemical properties and stability data of Resveratrol-polymer conjugates.
RSV-polymer conjugates | PLA Mw | PEG MW (Daltons) | % Conjugate Remaining at 24 hr pH 4.5 | % Conjugate Remaining at 24 hr pH 7.4 | Plasma t1/2 | CMC mg/L | CMC Moles/L |
---|---|---|---|---|---|---|---|
MeO-PEG-PLAO-Succ-RSV 2 kDa | 1000 | 750 | 99.2 | 104 | 3 hours | 4 | 0.002 |
MeO-PEG-PLAO-Succ-RSV 6.6 kDa | 4600 | 2000 | 78.4 | 78.7 | 5 minutes | 8 | 0.0012 |
MeO-PEGO-Succ-RSV 2 kDa | N/A | 2000 | 89.1 | 64.2 | <5 minutes | 500 | 0.25 |
MeO-PEGN-Succ-RSV 2 kDa | N/A | 2000 | 86.4 | 7.6 | <5 minutes | N/A | N/A |
MeO-PEGN-Succ-RSV20 kDa | N/A | 20000 | 88.1 | 9.3 | <5 minutes | N/A | N/A |
MeO-PEG-RSV ether 2 kDa | N/A | 2000 | 100 | 100 | No hydrolysis stable | N/A | N/A |
MeO-PEG-RSV ether 5 kDa | N/A | 5000 | 100 | 100 | No hydrolysis stable | N/A | N/A |
N/A: not applicable as conjugates are soluble.