Skip to main content
. 2015 Mar 23;10(3):e0118824. doi: 10.1371/journal.pone.0118824

Table 1. Physicochemical properties and stability data of Resveratrol-polymer conjugates.

RSV-polymer conjugates PLA Mw PEG MW (Daltons) % Conjugate Remaining at 24 hr pH 4.5 % Conjugate Remaining at 24 hr pH 7.4 Plasma t1/2 CMC mg/L CMC Moles/L
MeO-PEG-PLAO-Succ-RSV 2 kDa 1000 750 99.2 104 3 hours 4 0.002
MeO-PEG-PLAO-Succ-RSV 6.6 kDa 4600 2000 78.4 78.7 5 minutes 8 0.0012
MeO-PEGO-Succ-RSV 2 kDa N/A 2000 89.1 64.2 <5 minutes 500 0.25
MeO-PEGN-Succ-RSV 2 kDa N/A 2000 86.4 7.6 <5 minutes N/A N/A
MeO-PEGN-Succ-RSV20 kDa N/A 20000 88.1 9.3 <5 minutes N/A N/A
MeO-PEG-RSV ether 2 kDa N/A 2000 100 100 No hydrolysis stable N/A N/A
MeO-PEG-RSV ether 5 kDa N/A 5000 100 100 No hydrolysis stable N/A N/A

N/A: not applicable as conjugates are soluble.