Table 3. Pharmacokinetic parameters for resveratrol and its conjugate formulations in rats.
| AUC0-∞ | t½ | MRT ‡ | CL ‡ | Vss ‡ | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (μmol.h/L) | P value, 95% CI | (h) | P value, 95% CI | (h) | P value, 95% CI | (L/h/kg) | P value, 95% CI (Significance) | (L/kg) | P value, 95% CI (Significance) | |
| MeO-PEG-RSV ether 5 kDa; 2 mg/kg † (n = 6) | 50 ± 15 | 0.0003*** | 5.3 ± 2.1 | 0.0086** | 5.9 ± 3.5 | 0.0361* | 0.19 ± 0.06 | 0.0003*** | 1.01 ± 0.41 | 0.009** |
| MeO-PEG-RSV ether 2 kDa; 2 mg/kg † (n = 5) | 74 ± 16 | 0.0001**** | 5.5 ± 1.4 | 0.015** | 7.1 ± 2.0 | 0.0012** | 0.12 ± 0.02 | 0.001*** | 0.87 ± 0.28 | 0.0170* |
| MeO-PEG-PLAO-Succ-RSV 2kDa; 2 mg/kg † (n = 6) | 21 ± 17 | 0.0645 | 1.7 ± 0.5 | 0.512 | 1.9 ± 0.4 | 0.214 | 0.58 ± 0.26 | 0.0004*** | 1.12 ± 0.60 | 0.0094** |
| Resveratrol; 10 mg/kg † (n = 4) | 2.4 ± 0.7 | Not applicable | 1.4 ± 0.9 | Not applicable | 1.3 ± 1.0 | Not applicable | 20.1 ± 8.4 | Not applicable | 26.8 ± 19.1 | Not applicable |
† 2 mg/kg = 8.8 μmol/kg; 10 mg/kg = 44 μmol/kg. Doses are resveratrol equivalents† and data are mean ± SD.
‡ MRT: mean residence time;
CL: clearance; Vss: volume of distribution at steady-state.
P values are from comparison of a particular group against resvertrol,
* ** *** **** indicate p <0.05, increasing number of stars implies increasing significance.