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. 2015 Mar 23;10(3):e0121356. doi: 10.1371/journal.pone.0121356

Fig 7. Effect of the alteration in the ratio of level of (d20:1–20:0) to that of (d20:1–18:0) in GD1b-ganglioside on Aß assembly.

Fig 7

A, Addition of GD1b(d20:1–20:0) ganglioside to the lipids extracted from the amyloid-free precuneus significantly enhanced Aß assembly as determined by AFM. B, Addition of GD1b(d20:1–18:0) ganglioside to the lipids extracted from the amyloid-bearing precuneus significantly inhibited Aß assembly as determined by AFM. The subspecies of GD1b-ganglioside was purified from commercially available GD1b-gangliosides and added to the extent that its ratio equaled (center, × 1) or exceeded by four-fold (right, × 5) the original ratio in the lipids extracted from the amyloid-bearing precuneus. Scale bar, 500 nm.