Table 2. Imbalance of “a-series”-“b-series” composition in GD1(d20:1–20:0) in the brains harboring Aß deposition.
| a-series | b-series | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ceramide | P1 | C1 | P2 | C2 | P1 | C1 | P2 | C2 | ||||
| d18:1–18:0 | 6.58 (0.61) | > | 5.69 (0.57) | 6.91 (0.74) | > | 5.62 (0.53) | 14.64 (0.54) | < | 15.92 (0.91) | 14.45 (0.80) | < | 15.92 (0.77) |
| d20:1–18:0 | 14.36 (0.97) | > | 12.44 (1.38) | 14.43 (1.31) | > | 11.44 (1.03) | 37.3 (1.76) | < | 38.91 (1.68) | 37.54 (1.78) | < | 40.23 (0.96) |
| d20:1–20:0 | 1.18 (0.10) | > | 1.10 (0.14) | 1.34 (0.17) | > | 0.98 (0.07) | 3.07 (0.17) | < | 3.1 (0.09) | 3.39 (0.23) | > | 3.14 (0.20) |
Composition of GD1-gangliosides in relation to a- and b-series of gangliosides. The proportion of each ganglioside in detected gangliosides is expressed as mean with ± SEM in parentheses. P1, C1, P2, and C2 indicate lipid samples extracted from SPMs of the amyloid-free precuneus, the calcarine cortex of the brain with the amyloid-free precuneus, the amyloid-bearing precuneus, and the calcarine cortex of the brain with the amyloid-bearing precuneus, respectively.