Table 1.

Baseline characteristics at ICU admission of patients with subarachnoid hemorrhage stratified by EPHX2 genotype

Characteristics*	EPHX2 Genotype			p-value
	Wild Type (n=57)	K55R (n=14)	R287Q (n=24)
Age, years	54 ± 12	60 ± 15	53 ± 9	0.22
Male, n (%)	17 (29.8)	4 (28.6)	8 (33.3)	0.94
Caucasian, n (%)	47 (82.4)	14 (100)	14 (58.3)	0.006
Weight, kg	77 ± 20	78 ± 25	81 ± 15	0.66
Aneurysm Location, n (%)				0.73
ACA	2 (3.5)	0 (0)	0 (0)
ACOM	18 (31.6)	8 (57.1)	6 (25.0)
ICA/MCA	20 (35.1)	3 (21.4)	8 (33.3)
PCOM	7 (12.3)	2 (14.3)	4 (16.7)
PCA	1 (1.8)	0 (0)	1 (4.2)
Vertebro-basilar	9 (15.8)	1 (7.1)	5 (20.8)
Fisher grade ≥ 3	51 (89.5)	14 (100)	22 (91.7)	0.45
Hunt/Hess score, n (%)				0.70
1	6 (10.5)	1 (7.1)	3 (12.5)
2	15 (26.3)	2 (14.3)	7 (29.2)
3	12 (21.1)	7 (50.0)	6 (25.0)
4	14 (24.6)	2 (14.3)	5 (20.8)
5	10 (17.5)	2 (14.3)	2 (12.5)
Glasgow Coma Scale, median (IQR)	12 (6–15)	12 (8–14)	13.5 (6–15)	0.93
SAPS II	30.0 ± 13.5	32.6 ± 9.0	27.3 ± 14.1	0.46
Hematocrit, %	39.7 ± 4.2	40.1 ± 3.6	38.5 ± 4.6	0.46
WBC count, x 103/μL	15.6 ± 5.2	18.4 ± 14.1	13.6 ± 5.5	0.16
WBC count > 20,000/μL, n (%)	24 (42.1)	8 (57.1)	4 (16.7)	0.027
Troponin > 0.40 ng/ml, n (%)	8 (14.0)	4 (28.6)	4 (16.7)	0.43
Serum glucose, mg/dl	155 ± 43	179 ± 79	152 ± 35	0.21
Serum sodium, mEq/dl	137 ± 4.4	139 ± 3.0	138 ± 3.5	0.80
Serum creatinine, mg/dl	0.74 ± .18	0.81 ± 0.37	.76 ± 0.26	0.62
MAP, mmHg	87 ± 17	84 ± 12	86 ± 15	0.76
Prior anti-coagulation, n (%)	5 (8.8)	2 (14.3)	3 (12.5)	0.78
Intervention, n (%)				0.96
Craniotomy	39 (68.4)	10 (71.4)	17 (70.8)
Coil embolization	18 (31.6)	4 (26.7)	7 (29.2)

ACA anterior cerebral artery, ACOM anterior communication, ICA internal carotid artery, IQR interquartile range, MCA middle cerebral artery, PCOM posterior communicating, PCA posterior cerebral artery, SAPS II simplified acute physiology score, WBC peripheral white blood cell, MAP mean arterial pressure

^*Data are expressed as mean ± standard deviation unless otherwise specified