Table 1. Immunogenicity of inactivated influenza H7N9 whole virus vaccine in ferrets.
Group 1 | Group 2 | Group 3 | |
---|---|---|---|
HA (μg/dose) | 0 | 1.5 | 1.5 |
Al(OH)3 (μg/dose) | 300 | 0 | 300 |
No. of animals | 4 | 4 | 4 |
HI Seroconversion | |||
Prevaccination | 0/4 | 0/4 | 0/4 |
Post dose 1 | 0/4 | 0/4 | 4/4 |
Post dose 2 | 0/4 | 4/4 | 4/4 |
HI GMT | |||
Prevaccination | <10 | <10 | <10 |
Post dose 1 | <10 | <10 | 48 (34–67) a |
Post dose 2 | <10 | 17 (9–33) | 190 (98–396) |
Nt Seroconversion | |||
Prevaccination | 0/4 | 0/4 | 0/4 |
Post dose 1 | 0/4 | 0/4 | 4/4 |
Post dose 2 | 0/4 | 4/4 | 4/4 |
Nt GMT | |||
Prevaccination | <40 | <40 | <40 |
Post dose 1 | <40 | <40 | 48 (34–67) |
Post dose 2 | <40 | 80 (30–213) | 640 (143–2189) |
aGeometric mean titers (95% confidence interval)