Table 2. Virus titers in vaccinated ferrets at 3 and 7 days post challenge (DPC) with wild-type influenza H7N9 virus.
| Group 1 | Group 2 | Group 3 | ||||
|---|---|---|---|---|---|---|
| Virus RNA copies | Virus RNA copies | Virus RNA copies | ||||
| (live virus titers) a | (live virus titers) a | (live virus titers) a | ||||
| Ferret ID | #180 | #188 | #184 | #187 | #181 | #191 |
| 3 DPC | ||||||
| Nasal turbinate | 6.3 (5.6) | 6.5 (2.2) | 5.9 (2.6) | 6.2 (2.3) | 3.7 (<1) | 4.3 (<1) |
| URT | <2 (ND) | 4.2 (1.9) | <2 (ND) | 4.3 (<1) | <2 (ND) | <2 (ND) |
| LRT | 2.4 (ND) | 4.5 (3.3) | <2 (ND) | 5.1 (<1) | <2 (ND) | <2 (ND) |
| HLN | <2 (ND) | 2.5 (ND) | <2 (ND) | 2.0 (ND) | <2 (ND) | <2 (ND) |
| Lung | 2.3 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) |
| Ferret ID | #194 | #197 | #190 | #199 | #198 | #201 |
| 7 DPC | ||||||
| Nasal turbinate | 5.9 (2.5) | 4.2 (<1) | 3.3 (<1) | 2.3 (<1) | 2.4 (<1) | <2 (<1) |
| URT | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) |
| LRT | 2.8 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) |
| HLN | 2.4 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) |
| Lung | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) | <2 (ND) |
aData are presented as log10/mg and quantification limits for virus RNA copies and live virus titers are 100 copies/mg and 10 TCID50/mg, respectively.
URT: upper respiratory tract (top 1/3 of trachea); LRT: lower respiratory tract (bottom 1/3 of trachea); HLN: hilar lymph node; ND: not determined.