Fig 4. Effect of SIRT1 and SIRT1 (H363Y) overexpression on skeletal muscle insulin sensitivity.

(A) Glucose uptake, (B) glycogen synthesis and (c) glycogen content of control (white bars) or overexpressing (Black bars) muscle. *p<0.01 for the main effect of glucose infusion using a two-way ANOVA. There was no significant interaction between glucose infusion and construct for any parameter measured. Data are expressed as means ± SEM. n = 4–12 animals.