Fig 5. Effect of SIRT1 and SIRT1 (H363Y) overexpression on skeletal muscle signaling intermediates.

(A) Insulin receptor (IR), (B) Akt and (C) acetyl-CoA carboxylase (ACC). *p<0.05 for the main effect of glucose infusion using a two-way ANOVA. There was no significant interaction between glucose infusion and construct for any parameter measured. Data are expressed as means ± SEM. n = 4–12 animals.