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. 2015 Mar 23;10(3):e0120496. doi: 10.1371/journal.pone.0120496

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© 2015 Parviainen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — A-B: After enter A549 cells, at 48 hours post infection, vaccinia viral particles begin their normal life cycle quickly: form replication centre (viral factory) in juxta-nuclear region manifested as a homogeneous, low-to-middle electron density, void of any organelles. The replication begins with formation of crescent (Cr), then immature virus (IV), immature virus with nucleoids (IVN), mature virus (MV). Many MV are wrapped by intracellular membrane from Trans-Golgi cistern, form intracellular enveloped virus (IEV). IEVs move towards cell periphery, fuss with cell membrane and obtained another envelope from cell membrane, finally they are released to extracellular space to form extracellular enveloped virus (EEV). Some EEV remain attached on cell membrane as cell associated extracellular enveloped virus (CEV). C-D Different intermediate particles from cells other than cells in a-b in high magnification.