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. 2015 Mar 23;10(3):e0121319. doi: 10.1371/journal.pone.0121319

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© 2015 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — (A) Overexpression of S100A6 resulted in a significant increase in the level of β-catenin mRNA in Panc-1 cells. (B) Real-time PCR revealed that S100A6 overexpression resulted in decreased expression of E-cadherin, and increased expression of N-cadherin and vimentin. (C) Western blotting revealed that S100A6 upregulated β-catenin on the protein level. (D) Representative statistical chart showing increased β-catenin protein levels, compared to the control. (E) Western blotting revealed that S100A6 overexpression resulted in altered expression of EMT-related markers. Specifically, protein expression of E-cadherin was decreased, whereas expression of N-cadherin and vimentin was increased. (F) The relative protein levels of E-cadherin, N-cadherin and vimentin differed significantly between the S100A6-overexpressing condition and the control. *p < 0.05; **p < 0.01; ***p < 0.001.