Table 2.

Associations between COW variants and intracranial DE^a

	Any DE	Anterior circulation DE	Posterior circulation DE
Total absent scoreb	1.27 (1.03–1.57)	1.13 (0.83 – 1.55)	1.35 (1.02– 1.78)
Anterior circulation	1.22 (0.72–2.0l)	1.30 (0.71 – 2.40)	0.89 (0.44– 1.81)
Posterior circulation	1.27 (0.91–1.79)	1.10 (0.73 – 1.64)	1.54 (1.01– 2.37)
Total hypoplastic scoreb	0.96 (0.78–1.17)	0.94 (0.74 – 1.19)	0.98 (0.76– 1.26)
Anterior circulation	1.06 (0.66–1.70)	0.99 (0.66 – 1.54)	1.13 (0.80– 1.61)
Posterior circulation	0.88 (0.68 – 1.13)	0.91 (0.68 – 1.22)	0.94 (0.69– 1.30)
Incomplete anterior COW	1.28 (0.75 – 2.18)	1.41 (0.77 – 2.62)	0.88 (0.42– 1.81)
Incomplete posterior COW	1.53 (1.02 – 2.29)	1.35 (0.75 – 2.44)	1.80 (0.92– 3.53)

^aAll estimates are adjusted for age, sex, race/ethnicity, HTN, DM, hypercholesterolemia and current smoking.

^bThe total absent and hypoplastic scores represent the sum of all absent or hypoplastic large arteries in the brain; posterior and anterior represent the partial sum corresponding to the arteries in either the anterior or the posterior circulation.