Table 2. Clinical severity and CSF inflammation indices of bacterial meningitis patients by rs17525495 genotype on study recruitment.
| total | TT | TT Summary | CT | CT Summary | CC | CC Summary | Test | |
|---|---|---|---|---|---|---|---|---|
| Characteristic | n | n | statistic a | n | statistic | n | statistic | statistic b |
| all BM | ||||||||
| Glascow coma score | 390 | 67 | 13 (10–15) | 168 | 13 (9.75–15) | 154 | 13 (9.35–15) | 0.99 |
| coma group C | 390 | |||||||
| - normal | 67 | 22 (33) | 168 | 58 (35) | 154 | 54 (35) | 0.91 | |
| - mild impairment | 23 (34) | 62 (37) | 49 (32) | |||||
| - moderate impairment | 14 (21) | 34 (20) | 32 (21) | |||||
| - severe impairment | 8 (12) | 14 (8) | 19 (12) | |||||
| opening pressure (cmHgCSF) | 306 | 48 | 21 (14–43) | 137 | 22 (16–50) | 121 | 25 (14–46) | 0.75 |
| CSF white cell count / mm3 | 389 | 66 | 4505 (2025–9042.5) | 168 | 2500 (1095–6788.5) | 155 | 3280 (825–8600) | 0.13 |
| CSF Neutrophil percentage | 386 | 66 | 90.5 (78.25–95) | 166 | 85 (77–92) | 154 | 90 (78–94) | 0.07 |
| CSF total number of Neutrophil / mm3 | 386 | 66 | 3733.3 (1571.5–7635) | 166 | 2184.7 (922.2–5764.5) | 154 | 2819.2 (666.9–7530.2) | 0.19 |
| Proportion of glucose in the CSF | 387 | 67 | 17 (8.5–34.5) | 166 | 25.5 (12–44.75) | 154 | 27 (11–46) | 0.13 |
| Albumin in CSF (mg/dl) | 382 | 66 | 265 (170–400) | 163 | 239 (143.5–406) | 153 | 228 (147–385) | 0.47 |
| definite BM | ||||||||
| Glascow coma score | 312 | 55 | 13 (9–15) | 133 | 13 (9–15) | 124 | 13 (9–15) | 0.8134 |
| coma group | 312 | |||||||
| - normal | 55 | 16 (29) | 133 | 44 (33) | 124 | 40 (32) | 0.80 | |
| - mild impairment | 19 (35) | 50 (38) | 40 (32) | |||||
| - moderate impairment | 12 (22) | 29 (22) | 29 (23) | |||||
| - severe impairment | 8 (15) | 10 (8) | 15 (12) | |||||
| opening pressure (cmHgCSF) | 245 | 38 | 25 (14.2–49.7) | 109 | 22 (17–50) | 98 | 25 (16.2–46) | 0.99 |
| CSF white cell count / mm3 | 311 | 54 | 4255 (1880–8952.5) | 133 | 2620 (1100–6790) | 124 | 3625 (847.5–9060.5) | 0.31 |
| CSF Neutrophil percentage | 308 | 54 | 91 (79.25–97.75) | 131 | 87 (78.5–93) | 123 | 90 (78–95) | 0.09 |
| CSF total number of Neutrophil / mm3 | 308 | 54 | 3530.1 (1571.5–7635) | 131 | 2352 (927–6054.5) | 123 | 3465 (685.4–8087.8) | 0.37 |
| Proportion of glucose in the CSF | 310 | 55 | 19 (9.5–34.5) | 132 | 26.5 (10–46) | 123 | 23 (9–46) | 0.13 |
| Albumin in CSF (mg/dl) | 305 | 54 | 270 (170–396.5) | 128 | 265 (148.5–428.5) | 123 | 248 (160.5–430) | 0.93 |
| TNF-alpha in CSF (pg/ml) | 126 | 23 | 812.95 (42.44–3550.55) | 52 | 91.12 (30.28–897.32) | 51 | 205.64 (37.68–3312.95) | 0.15 |
aSummary statistic is absolute count (%) for categorical variables and median (IQR) for continuous data
btest statistic for categorical variables is the χ 2 test (6 df), and for continuous variables is the Kruskall-Wallis test
C Glasgow coma score groups were defined as ‘normal’ if the score was 15/15, ‘mild impairment’ if the score was 13 or 14, ‘moderate impairment’ if the score was 11 or 12, and ‘severe impairment’ if the score was <11.