Table 2. Observed ulcer area, inhibition percentage, mucus content and serum analysis of zerumbone against ethanol-induced gastric ulcer in rats.
| Pre-treatment (mg/kg) | Ulcer area (mm 2) | Inhibition (%) | Mucus weight (g) | ALT(IU/L) | AST(IU/L) |
|---|---|---|---|---|---|
| Ulcer control | 178.48 ± 11.04 | NA | 0.89±0.2 | 55.4±2.71* | 292±2.15 |
| Normal control | 0 | 100 | 0.99±0.3 | 35.67±1.67* | 227±6.81 * |
| Omeprazole 20 | 41.44 ± 1.01* | 76.77 | 1.91±0.2* | 37±2.08 * | 274.67±3.01 * |
| Zerumbone 5 | 43.55 ± 2.00* | 75.59 | 1.56 ±0.4 * | 48.4±1.47 * | 278.04±2.02 * |
| Zerumbone 10 | 20.07 ± 1.09* | 88.75 | 1.78±0.1 * | 38.75±1.58 * | 271.6±6.22 * |
NA; not applicable; AST, Aspartate transaminase; ALT, Alanine Aminotranferase. Data are expressed as mean ± S.E.M. (n = 6),
*p < 0.05; significant vs. ulcer control. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Dunnett’t test for multiple comparison.