Table 2.
Comparisons of characteristic features of patients with asthma and ACOS
| All
|
Asthma
|
ACOS
|
P-value | |
|---|---|---|---|---|
| (n=650) | (n=474) | (n=176) | ||
| Age, years, mean ± SD | 64.4±16.4 | 61.7±17.1 | 71.6±11.0 | <0.0001 |
| Sex, n (%) | ||||
| Male | 328 (50.5%) | 169 (35.7%) | 159 (90.3%) | <0.0001 |
| Female | 322 (49.5%) | 305 (64.3%) | 17 (9.7%) | |
| Smoking status, n (%) | ||||
| Current/ex-smoker | 324 (49.8%) | 148 (31.2%) | 176 (100.0%) | <0.0001 |
| Non-smoker | 326 (50.2%) | 326 (68.8%) | 0 (0.0%) | |
| FEV1/FVC, %, mean ± SD | 69.1±13.7 | 74.0±10.9 | 55.9±11.6 | <0.0001 |
| %FEV1 predicted, %, mean ± SD | 89.1±26.2 | 93.4±24.7 | 77.9±26.8 | <0.0001 |
| IgE, IU/L, mean ± SD | 532.6±1,576.3 | 469.3±1,557.2 | 711.1±1,620.9 | 0.0870 |
| Malignancies, n (%) | 149 (22.9%) | 92 (19.4%) | 57 (32.4%) | 0.0017 |
| Living, n (%) | 563 (86.6%) | 420 (88.6%) | 143 (81.3%) | 0.0192 |
| Deceased, n (%) | 87 (13.4%) | 54 (11.4%) | 33 (18.7%) | |
Abbreviations: ACOS, asthma–COPD overlap syndrome; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; IgE, immunoglobulin E; SD, standard deviation; IU/L, international unit per liter.