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. 2015 Mar 23;10(3):e0121803. doi: 10.1371/journal.pone.0121803

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© 2015 Jeong et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Neutralizing antibodies for CNTFRα (CNTFRα-NA) were injected in rats 3 weeks after the intranigral injection of AAV-hRheb(S16H). Following this, rats were injected into the MFB with MPP⁺. Representative coronal sections of the SN and STR of TH immunoperoxidase staining showed that CNTFRα neutralization attenuated the protective effects induced by hRheb(S16H) against MPP⁺ neurotoxicity. CON, contralateral control side; EXP, ipsilateral injected side. Scale bars represent 500 μm and 10 μm in the SN, respectively, and 500 μm in the STR. (B and C) The quantitative analysis of TH-positive neurons and fibers demonstrated that treatment with neutralizing antibodies for CNTFRα significantly decreased the hRheb(S16H)-induced neuroprotection on the nigrostriatal projection. All values are expressed as a percentage of the results in the ipsilateral SN and STR, respectively, compared with the contralateral controls (One-way ANOVA and Tukey post-hoc analysis; n = 4, each group).